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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T21498 | Phleomycin | DNA/RNA Synthesis , Antibacterial , Antibiotic | |
Phleomycin is one of the anticancer glycopeptide antibiotics which cause DNA cleavage. It is similar to Bleomycin which binds and intercalates DNA to damage the integrity of the double helix. | |||
T8873 | Bractoppin | Others , DNA/RNA Synthesis | |
Bractoppin is a drug-like inhibitor of phosphopeptide recognition by the human BRCA1 tandem (t)BRCT domain (IC50 = 0.074 μM), which selectively inhibits substrate binding with nanomolar potency in vitro. Structure-activi... | |||
T38272 | Thiacloprid | AChR , Parasite | |
Thiacloprid is a neonicotinoid insecticide that acts as a selective agonist at insect nicotinic acetylcholine receptors (nAChRs) with IC50values of 2.7 and 860 nM forDrosophilanAChRs and M10 mouse fibroblast cells expres... | |||
T3103 | L67 | DNA Ligase Inhibitor | DNA , DNA/RNA Synthesis |
L67 (DNA Ligase Inhibitor) is a competitive human DNA ligase inhibitor, inhibits DNA ligases I and III (IC50: 10 μM). | |||
T1767 | BMH-21 | BMH21 | DNA/RNA Synthesis |
BMH-21, a small molecule DNA intercalator, binds ribosomal DNA and inhibits RNA polymerase I (Pol I) transcription and not affects phosphorylation of H2AX. | |||
T1564 | Cisplatin | cis-Diaminodichloroplatinum,CDDP | DNA Alkylator/Crosslinker , Ferroptosis , DNA/RNA Synthesis , Autophagy |
Cisplatin (CDDP) is a DNA cross-linking agent. Cisplatin has antitumor activity and inhibits DNA synthesis by forming DNA adducts in cancer cells. Cisplatin also activates iron death and induces autophagy. | |||
T9271 | RAD51-IN-1 | DNA/RNA Synthesis | |
Rad51-in-1 is a derivative of B02 and an effective inhibitor of Rad51. | |||
T4470 | Pyridostatin TFA | DNA/RNA Synthesis | |
Pyridostatin Trifluoroacetate Salt is a G-quadruplexe stabilizer with Kd of 490 nM in a cell-free assay, which targets a series of proto-oncogenes including c-kit, K-ras and Bcl-2. | |||
T27029 | Cjoc42 | cjoc 42,cjoc-42 | |
Cjoc42 is an inhibitor of gankyrin, an ankyrin-repeat oncoprotein whose overexpression has been implicated in the development of many cancer types. cjoc42 prevents the decrease in p53 protein levels normally associated w... | |||
T9849 | HQ461 | CDK , Molecular Glues | |
HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death. | |||
T9497 | Niraparib tosylate monohyrate | PARP | |
Niraparib, also know as MK-4827, is an inhibitor of poly (ADP-ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting... | |||
T5399 | GeA-69 | PARP | |
GeA-69 (GeA69) is a selective and allosteric PARP14 macrodomain 2 (MD2) inhibitor (Kd: 0.86 μM in ITC assays). | |||
T8869 | B355252 | Others | |
B355252 protects against cell death caused by glutamate-evoked oxidative stress. B355252 shows neuroprotective effect, potentiating nerve growth factor (NGF)-induced neurite outgrowth. | |||
T6303 | CCT128930 | Akt , PKA , S6 Kinase , Autophagy | |
CCT128930 is a potent, ATP-competitive and selective inhibitor of Akt2 with IC50 of 6 nM, 28-fold greater selectivity for Akt2 than the closely related PKA kinase. | |||
T8492 | BO-264 | Apoptosis , FGFR | |
BO-264 is a highly potent and orally active inhibitor of transforming acidic coiled-coil 3 (TACC3, IC50 of 188 nM and a Kd of 1.5 nM). | |||
T1899 | Pyridostatin | RR82,Pyridostatin Trifluoroacetate Salt | DNA/RNA Synthesis |
Pyridostatin (RR82) is a synthetic small-molecule stabilizer of G-quadruplexes, a secondary structure of DNA that usually exists in the end of the chromosome or the telomeres. | |||
T1640 | Ciprofloxacin | Ciproxan,Ciprobay,Bay o 9867,Bay-09867 | Topoisomerase , Antibacterial , Antibiotic |
Ciprofloxacin (Bay-09867), a synthetic broad spectrum fluoroquinolone antibiotic, inhibits bacterial DNA gyrase. It is more active against Gram-negative bacteria than Gram-positive bacteria. | |||
T9024 | OUL35 | NSC39047 | Others , PARP |
OUL35 (NSC-39047) is a selective PARP-10 inhibitor, and small-molecule ARTD10 inhibitor. OUL35 has been shown to rescue cells from ARTD10-induced cell death. | |||
T3231 | Niraparib | MK-4827 | Apoptosis , Others , PARP |
Niraparib (MK-4827) is a PARP inhibitor that selectively inhibits PARP1 and PARP2 (IC50=3.8/2.1 nM). Niraparib has antitumor activity, inhibits DNA damage repair, and induces apoptosis. | |||
T7318 | Elimusertib | BAY-1895344 | ATM/ATR |
Elimusertib (BAY-1895344) is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.Elimusertib shows potent anti-tumor efficacy in monotherapy and strong combination potential with the target... |